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Diflucan is usually taken by mouth as a one-time only dose with or without food or as directed by your doctor. If you are allergic to it or to other antifungal drugs. Fluconazole will not treat a viral infection such as the common cold or flu. Diflucan comes as a tablet and liquid to take by mouth usually taken once a day. Fluconazole is used to treat vaginal yeast infections. Fluconazole is a triazole antifungal agent that may be an easier treatment than a messy cream. In your body is kept at a constant level. Fluconazole will not treat a viral infection such as the common cold or flu. Fluconazole works best if it is taken at the same time each day.