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Prednisolone works by acting within cells to prevent the release of substances in the body that cause inflammation. Corticosteroid medicine. Since prednisone is used in so many conditions, only the most common or established uses are mentioned here. Before taking Prednisolone, you should tell your doctor about all of your medical conditions and about all other medicines you are using. Prednisone is used in much higher doses than the levels of corticosteroids produced naturally by the body.